Pharmacokinetic, Pharmacodynamic, and Activity Evaluation of TMX-101 in a Multicenter Phase 1 Study in Patients With Papillary Non-Muscle-Invasive Bladder Cancer.

Clinical Genitourinary Cancer 2015;13(3):204-9.e2. Arends TJ, Lammers RJ, Falke J, van der Heijden AG, Rustighini I, Pozzi R, Ravic M, Eisenhardt A, Vergunst H, Witjes JA. INTRODUCTION/BACKGROUND: Non-muscle-invasive bladder cancer (NMIBC) has a strong tendency to recur despite adjuvant instillations. TMX-101 … Continue reading

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Mitogel: Optimizing drug delivery to the upper urinary tract— a preclinical evaluation

Journal of Urology 2014;191(4):e914. Meiron M, Chamie K, Lerner SP, Jeshurun M, Hakim G, Schoenberg MP, et al.

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Results of a phase 1 dose escalation study of intravesical TMX-101 in patients with nonmuscle invasive bladder cancer.

The Journal of Urology 2013;189(6):2077–82. Falke JJ, Lammers RJ, Arentsen HC, Ravic M, Possi R, Cornel EB, Vergunst H, deReijke TM, Witjes JA. PURPOSE: Imiquimod, a toll like receptor 7 (TLR-7) agonist, is effective as a topical treatment for skin malignancies. … Continue reading

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